The Drug-Induced Cardiotoxicity Website and App

XXIV.e

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

Relapsing or migrating pneumonitis/pneumonia (see also Id)

Last update 17/06/2026

Relapsing episodes of pneumonitis or areas of consolidation on 1-continued exposure to the drug, 2-following patient rechallenge, or 3-following drug discontinuance ('aftershock') may occur, especially following corticosteroid taper or withdrawal (PMID 30572331°. Amiodarone, statins and immune chekpoints can produce episodes of relapsing pneumonitis or BOOP, even though the drug has been discontinued 5pmid 30572331°

Causative drugs

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic