The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIX.a

Bronchospasm - Wheezing - Asthma

Can be life-threatening. Risk varies with beta-1 selectivity (PMID 24202435). Persistent asthma occasionally follows beta-blocker-induced bronchospasm (PMID 45308)

Publications

Wu JH, Jerng JS, Su CC

Insidious-onset, non-wheezing carteolol-induced asthma in an atopic patient without asthma history.

BMJ case reports. 2019;12(4)

Morales DR, Jackson C, Lipworth BJ, Donnan PT, Guthrie B

Adverse respiratory effect of acute β-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials.

Chest. 2014;145(4):779-786

Shepherd D, Adams S, Wargon O, Jaffe A

Childhood wheeze while taking propranolol for treatment of infantile hemangiomas.

Pediatric pulmonology. 2012;47(7):713-5

Miki A, Tanaka Y, Ohtani H, Sawada Y

Betaxolol-induced deterioration of asthma and a pharmacodynamic analysis based on beta-receptor occupancy.

International journal of clinical pharmacology and therapeutics. 2003;41(8):358-64

Hoigné RV, Braunschweig S, Zehnder D, Kuenzi UP, Hess T, Leuenberger P

Drug-induced attack of bronchial asthma in inpatients: a 20-year survey of the Comprehensive Hospital Drug Monitoring Programme on adverse drug reactions, Berne/St. Gallen.

European journal of clinical pharmacology. 1997;53(1):81-2

Patakas D, Argiropoulou V, Louridas G, Tsara V

Beta-blockers in bronchial asthma: effect of propranolol and pindolol on large and small airways.

Thorax. 1983;38(2):108-12

Lawrence DS, Sahay JN, Chatterjee SS, Cruickshank JM

Asthma and beta-blockers.

European journal of clinical pharmacology. 1982;22(6):501-9

Anderson EG, Calcraft B, Jariwalla AG, Al-Zaibak M

Persistent asthma after treatment with beta-blocking agents.

British journal of diseases of the chest. 1979;73(4):407-8

Decalmer PB, Chatterjee SS, Cruickshank JM, Benson MK, Sterling GM

Beta-blockers and asthma.

British heart journal. 1978;40(2):184-9