The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.f

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

Publications

Nacca N, Bhamidipati CM, Yuhico LS, Pinnamaneni S, Szombathy T

Severe amiodarone induced pulmonary toxicity.

Journal of thoracic disease. 2012;4(6):667-70

Galindo-Filho VC, Brandão DC, Ferreira Rde C, Menezes MJ, Almeida-Filho P, Parreira VF, Silva TN, Rodrigues-Machado Mda G, Dean E, Dornelas de Andrade A

Noninvasive ventilation coupled with nebulization during asthma crises: a randomized controlled trial.

Respiratory care. 2013;58(2):241-9

Argyriou M, Hountis P, Antonopoulos N, Mathioudaki M

Acute fatal post-CABG low dose amiodarone lung toxicity.

Asian cardiovascular & thoracic annals. 2007;15(6):e66-8

Parambil JG, Myers JL, Aubry MC, Ryu JH

Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy.

Chest. 2007;132(1):50-7