The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Left or biventricular dysfunction/failure

Can occur through amiodarone-induced thyroid dysfunction

Publications

O'Sullivan AJ, Lewis M, Diamond T

Amiodarone-induced thyrotoxicosis: left ventricular dysfunction is associated with increased mortality.

European journal of endocrinology. 2006;154(4):533-6

Gottlieb SS, Riggio DW, Lauria S, Peters RW, Shorofsky SR, Cines M, Froman D, Gold MR

High dose oral amiodarone loading exerts important hemodynamic actions in patients with congestive heart failure.

Journal of the American College of Cardiology. 1994;23(3):560-4