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XXIV.t

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

ILD with a granulomatous component

Last update 11/09/2026

(Fr: PnP avec granulomes). 2018 review at PMID 29698718. Characteristically nonnecrotizing, noninfectious, sterile granulomas. Although this is a pathologic pattern, the condition is suspected on a miliary appearance on imaging. Hilar/mediastinal lymphadenopathy can be present. May mimic pulmonary and/or systemic sarcoidosis. Concomittant skin lesions may show granulomas. A confirmarptory lung biopsy may be required (See under Pathology XIV). Careful exclusion of mycobacterial, fungal and Pneumocystis infection is crucial (See PMID 10678649, 18054121, 17257125).

Causative drugs

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic