The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXII.b

ARDS - Acute lung injury

Publications

Rejlekova K, Cursano MC, De Giorgi U, Mego M

Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome.

Frontiers in endocrinology. 2019;10:218

Park HC, Ahn JS, Yang DH, Jung SH, Oh IJ, Choi S, Lee SS, Kim MY, Kim YK, Kim HJ, Lee JJ

Fatal Interstitial Pneumonitis Rapidly Developed after the First Cycle of CHOP with Etoposide Combination Chemotherapy in a Patient with Lymphoma.

Tuberculosis and respiratory diseases. 2013;74(5):235-9

Dhokarh R, Li G, Schmickl CN, Kashyap R, Assudani J, Limper AH, Gajic O

Drug-associated acute lung injury: a population-based cohort study.

Chest. 2012;142(4):845-850

Kelsey CR, Horwitz ME, Chino JP, Craciunescu O, Steffey B, Folz RJ, Chao NJ, Rizzieri DA, Marks LB

Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors.

International journal of radiation oncology, biology, physics. 2011;81(3):812-8

Beasley MB

The pathologist's approach to acute lung injury.

Archives of pathology & laboratory medicine. 2010;134(5):719-27

Ki KD, Lee JM, Lee SK, Tong SY, Huh CY, Ryu JK, Kim KY

Pulmonary toxicity after a quick course of combinatorial vincristine, bleomycin, and cisplatin neoadjuvant chemotherapy in cervical cancer.

Journal of Korean medical science. 2010;25(2):240-4

Leslie KO

My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Journal of clinical pathology. 2009;62(5):387-401

Bredenfeld H, Franklin J, Nogova L, Josting A, Fries S, Mailänder V, Oertel J, Diehl V, Engert A, German Hodgkin's Lymphoma Study Group

Severe pulmonary toxicity in patients with advanced-stage Hodgkin's disease treated with a modified bleomycin, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone, and gemcitabine (BEACOPP) regimen is probably related to the combination o

Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2004;22(12):2424-9

Fassas A, Gojo I, Rapoport A, Cottler-Fox M, Meisenberg B, Papadimitriou JC, Tricot G

Pulmonary toxicity syndrome following CDEP (cyclophosphamide, dexamethasone, etoposide, cisplatin) chemotherapy.

Bone marrow transplantation. 2001;28(4):399-403

Kornek GV, Haider K, Kwasny W, Hejna M, Raderer M, Meghdadi S, Burger D, Schneeweiss B, Depisch D, Scheithauer W

Effective treatment of advanced breast cancer with vinorelbine, mitomycin C plus human granulocyte colony-stimulating factor.

British journal of cancer. 1996;74(10):1668-73

White DA, Orenstein M, Godwin TA, Stover DE

Chemotherapy-associated pulmonary toxic reactions during treatment for breast cancer.

Archives of internal medicine. 1984;144(5):953-6

Sostman HD, Putman CE, Gamsu G

Review: diagnosis of chemotherapy lung.

AJR. American journal of roentgenology. 1981;136(1):33-40