The Drug-Induced Cardiotoxicity Website and App

XXXVI.b

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

Lupus - Lupus syndrome (see also Vd)

Last update 28/12/2019

Patients with drug-induced lupus may present with serositis (See Vd). Review at PMID 20015613. Compendium of 118 drugs causing lupus from the Who Phamacovigilance Database available at PMID 30793701. A few drugs (Penicillamine, IFN, anti-TNF agents) can cause +ds-DNA lupus. Drug withdrawal is followed by abatement of signs, symptoms and diminution or disappearance of anti-nuclear antibodies (ANA)

Causative drugs

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic