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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII - Pericardial involvement

XII.b

Pericardial effusion (w/wo tamponade)
XII.e

Constrictive pericarditis - Pericardial thickening
XII.g

Pleural/pericardial effusion, ANA positive (DI lupus)
XII.n

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XV - Chest pain

XV.e

Pleuritis (can cause chest pain)

XVI - Hemorrhage - Bleeding - Hematoma

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI.g

Alveolar hemorrhage, diffuse (ANCA-positive/-related)

XX - Vasculitis

XX.c

Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)
XX.d

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

ARDS - Acute lung injury

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (interstitial lung disease/ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)
XXIV.k

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

XXVIII - Large airway involvement including UAO

XXVIII.a

Angioedema (may cause UAO, asphyxia and death)
XXVIII.d

Vocal cord dysfunction, adduction, closure, injury

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma
XXIX.b

Occupational asthma

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.a

Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)
XXXVI.b

Lupus - Lupus syndrome (see also Vd)
XXXVI.m

DRES syndrome - DRESS-like reaction
XXXVI.s

Dual MPO-/PR3-ANCA systemic disease/vasculitis/pseudovasculitis
XXXVI.t

Pneumorenal syndrome (w/wo ANCAs)
XXXVI.u

Pulmonary vasculitis or capillaritis

XXXVIII - Miscellaneous - Varia

XXXVIII.a

Upper airway obstruction other than angioedema or hematoma
XXXVIII.c

Antiphospholipid antibodies w/wo the APL syndrome