The Drug-Induced Cardiotoxicity Website and App

XXXIII.k

XXXIII - Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

Path: Alveolar hemorrhage (see also IIIa)

Last update 02/09/2026

Diffuse alveolar hemorrhage (DAH). Diagnosed by either fresh hemorrhage denoting recent active bleeding, stainable iron in macrophages (the Gold score) and/or capillaritis. See also 'Path: capillaritis' and BAL cytology under hemorrhage

Causative drugs

5

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

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