The Drug-Induced Cardiotoxicity Website and App

I. Myocardial dysfunction - Heart failure

I.a Left or biventricular dysfunction/failure

I. Myocardial dysfunction - Heart failure

I.d Cardiovascular collapse - Cardiogenic shock - Hypotension

I. Myocardial dysfunction - Heart failure

I.g Heart failure (thyrotoxicosis-, thyroid storm-mediated)

II. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.g QTc prolongation

II. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.i Torsades de pointe

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

XI. Pulmonary vasculopathies

XI.b Acute pulmonary hypertension

XII. Pericardial involvement

XII.g Pleural/pericardial effusion, ANA positive (DI lupus)

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thromboembolism

XIV. Pleural involvement

XIV.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

XIV. Pleural involvement

XIV.h Pleural thickening - Fibrothorax

XV. Chest pain

XV.b Pleuritic chest pain

XVI. Hemorrhage - Bleeding - Hematoma

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma

XVI.i Hemoptysis

XXII. Acute respiratory/cardiorespiratory failure

XXII.b ARDS - Acute lung injury

XXII. Acute respiratory/cardiorespiratory failure

XXII.d Postoperative ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.e Relapsing or migrating pneumonitis/pneumonia (see also Id)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.f Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.g Amiodarone pulmonary toxicity - Amiodarone lung

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.h Pulmonary fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Organizing pneumonia pattern (an area or areas of consolidation on imaging)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.l Pulmonary infiltrates

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.m Acute fibrinous organizing pneumonia (AFOP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.o A mass or masses

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.p Rapidly progressive ILD/pulmonary fibrosis (a.k.a. Hamman-Rich syndrome)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.q An area or areas of consolidation

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.s Lung nodule or nodules

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.aa Unilateral interstitial lung disease

XXV. Pulmonary function - Pulmonary physiology - PFTs

XXV.g Platypnea-orthodeoxia

XXVI. Neuromuscular dysfunction

XXVI.b Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

XXVI. Neuromuscular dysfunction

XXVI.d Acute respiratory failure (hypoxemia, acidosis) from myxedema (-coma)

XXVIII. Large airway involvement including UAO

XXVIII.h Airway pigmentation (black, bluish, petechial)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXX. Imaging features

XXX.o Imaging: Lung nodule or nodules

XXX. Imaging features

XXX.p Imaging: Asymmetrical, predominantly unilateral involvement

XXX. Imaging features

XXX.r Imaging: Waxing and waning nodules

XXXI. Eye catchers

XXXI.f Eye-catcher: An electron-dense liver on unenhanced CT

XXXI. Eye catchers

XXXI.g Eye-catcher: An electron-dense ('white') thyroid

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.y Path: Acute fibrinous organizing pneumonia (AFOP-pattern)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.b Lupus - Lupus syndrome (see also Vd)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

XXXVIII. Miscellaneous - Varia

XXXVIII.g Bluish, pseudocyanotic skin discoloration

II. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.b Atrial fibrillation

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VIII. Valvular heart disease

VIII.a Valvular heart disease and/or dysfunction

X. Pulmonary edema - ALI/ARDS

X.a Pulmonary edema, cardiogenic

X. Pulmonary edema - ALI/ARDS

X.f Capillary leak syndrome (CLS)

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XI. Pulmonary vasculopathies

XI.i Pulmonary veno-occlusive disease

XIV. Pleural involvement

XIV.f Pneumothorax

XIV. Pleural involvement

XIV.l Pneumothorax, bilateral

XIV. Pleural involvement

XIV.o Pleuroparenchymal fibroelastosis (PPFE)

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XXI. Mediastinal involvement/injury

XXI.c Pneumomediastinum

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Progression, acceleration or exacerbation of preexisting ILD/fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.n Subclinical pulmonary infiltrates/ILD

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.t ILD with a granulomatous component

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ad Pulmonary alveolar proteinosis (PAP) (secondary)

XXVI. Neuromuscular dysfunction

XXVI.a Phrenic nerve injury - Hemi- or bilateral diaphragmatic paralysis

XXVIII. Large airway involvement including UAO

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXX. Imaging features

XXX.i Imaging: Cavitating/cavitary lung nodule, mass or nodules (see also Iq, XIs, XIIi, XVIaa and XVIIp)

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.m Path: Pulmonary veno-occlusive disease (PVOD)

XXXIV. Infections

XXXIV.e Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

XXXIV. Infections

XXXIV.f Opportunistic pulmonary/systemic infections

XXXIV. Infections

XXXIV.g Pneumocystis jiroveci pneumonia

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.c Sarcoid-like granulomatosis (endo-/extrathoracic)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.q Tumor lysis syndrome (TLS)

XXXVIII. Miscellaneous - Varia

XXXVIII.k Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

XXXVIII. Miscellaneous - Varia

XXXVIII.n Hiccup

XXXVIII. Miscellaneous - Varia

XXXVIII.y Neutropenia, agranulocytosis (w/wo infection/sepsis)

II. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.e Bradycardia

XV. Chest pain

XV.d Chest tightness

XVI. Hemorrhage - Bleeding - Hematoma

XVI.h Coagulopathy

XVI. Hemorrhage - Bleeding - Hematoma

XVI.m Gross or microscopic bleeding/hemorrhage in lung tissue

XVII. Heart injury/trauma/perforation

XVII.b Facial/labial/buccal/oral/dental trauma

XXII. Acute respiratory/cardiorespiratory failure

XXII.c Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.z Exogenous lipoid pneumonia (subacute, acute)

XXVII. Dyspnea, lone

XXVII.a Dyspnea, unexplained otherwise

XXVIII. Large airway involvement including UAO

XXVIII.b Epiglottitis

XXVIII. Large airway involvement including UAO

XXVIII.g Thermal (burns, frostbite), chemical or caustic injury on the face, mouth, tongue, pharynx or upper airway

XXVIII. Large airway involvement including UAO

XXVIII.l Sputum production - Bonchorrhea - ‘Bronchitis’

XXVIII. Large airway involvement including UAO

XXVIII.m Bronchiectasis

XXIX. Small airway involvement

XXIX.c Severe or catastrophic bronchospasm or asthma attack (can be fatal)

XXIX. Small airway involvement

XXIX.d Cough (lone)

XXIX. Small airway involvement

XXIX.f Deterioration/exacerbation of preexisting asthma or COPD

XXIX. Small airway involvement

XXIX.m Obstructive airway dysfunction (see also IVc, XVx)

XXIX. Small airway involvement

XXIX.n Reactive airway dysfunction syndrome (RADS)

XXX. Imaging features

XXX.e Imaging: An area or areas of consolidation

XXX. Imaging features

XXX.f Imaging: Alveolar opacities or haze with a batwing or butterfly distribution

XXX. Imaging features

XXX.k Imaging: Centrilobular micronodules (can be diffuse)

XXX. Imaging features

XXX.l Imaging: Ground-glass opacities (GGO) / shadowing

XXX. Imaging features

XXX.n Imaging: A 'tree-in-bud' pattern

XXX. Imaging features

XXX.ab Imaging: Diffuse haze

XXXI. Eye catchers

XXXI.e Eye catcher: A batwing pattern on imaging

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.k Path: Alveolar hemorrhage (see also IIIa)

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.x Granulomatous mediastinal lymphadenopathy

XXXIV. Infections

XXXIV.b Respiratory tract infection incl. pneumonia

XXXIV. Infections

XXXIV.h Nontuberculous pulmonary mycobacterial infection/superinfection

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.p Systemic inflammatory response

XXXVIII. Miscellaneous - Varia

XXXVIII.c Antiphospholipid antibodies w/wo the APL syndrome

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

I. Myocardial dysfunction - Heart failure

I.c Heart failure (biventricular, congestive)

II. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.m Sudden cardiac death

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.a Myocarditis (can be fulminant)

V. Myocarditis

V.e Necrotizing myocarditis (w/o evidence for CAD)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

VII. Cardiotoxicity

VII.a Cardiotoxicity

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XIV. Pleural involvement

XIV.i Serositis - Polyserositis

XV. Chest pain

XV.e Pleuritis (can cause chest pain)

XXI. Mediastinal involvement/injury

XXI.a Lymphadenopathy (intrathoracic)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (interstitial lung disease/ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.r Delayed ILD, -pneumonitis, -fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.w Radiation recall pneumonitis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ac Chronic pneumonitis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ae Shrinking lung syndrome

XXIX. Small airway involvement

XXIX.i Exacerbation or deterioration of preexisting COPD

XXX. Imaging features

XXX.h Imaging: Avid pleural uptake on PET-scan

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.f Path: Myocardial vasculitis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.v Temporal arteritis (Horton’s)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.aj The association of ILD and myositis

X. Pulmonary edema - ALI/ARDS

X.b Pulmonary edema, noncardiogenic (NCPE)

XXIII. Hemoglobinopathies (acquired, reversible)

XXIII.a Methemoglobinemia

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.al Irreversible respiratory damage requiring lung Tx

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.a Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.e ANCA positivity. Subclinical or with clinical manifestations

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m DRES syndrome - DRESS-like reaction