The Drug-Induced Cardiotoxicity Website and App

III.c

III - Myocardial ischemia - Coronary artery disease

Coronary vasospasm - Vasospastic angina

Last update 06/09/2020

Classically in the form of acute ST changes on EKG, acute coronary event or MI (See under XIIg). After episode, coronary bed/angiogram returns to the patent state. May happen without preexisting/underlying CAD

Causative drugs

12

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.d
I.g
II.g
XI.b
XII.b
XII.g
XIII.a
XIV.a
XIV.h
XV.b
XVI.e
XXII.b
XXII.d
XXIV.a
XXIV.b
XXIV.c
XXIV.e
XXIV.f
XXIV.g
XXIV.h
XXIV.k
XXIV.m
XXIV.n
XXIV.o
XXIV.p
XXIV.q
XXIV.r
XXIV.s
XXIV.aa
XXIV.ac
XXV.g
XXVI.b
XXVI.d
XXVIII.h
XXIX.d
XXX.i
XXX.l
XXX.o
XXX.p
XXX.r
XXXI.f
XXXI.g
XXXIII.k
XXXIII.y
XXXIV.g
XXXVI.b
XXXVI.f
XXXVI.p
XXXVIII.g