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The Drug-Induced Cardiotoxicity Website and App

CAR T-cell therapy

Specialities: Oncology

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Myocardial dysfunction - Heart failure

I.a

Left or biventricular dysfunction/failure
I.c

Heart failure (biventricular, congestive)
I.d

Cardiovascular collapse - Cardiogenic shock - Hypotension
I.e

Acute respiratory or cardiopulmonary failure

II - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.a

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
II.f

Tachycardia
II.g

QTc prolongation
II.l

Cardiac- cardiorespiratory/pulmonary arrest

III - Myocardial ischemia - Coronary artery disease

III.c

Coronary vasospasm - Vasospastic angina
III.g

ST segment changes

VI - Cardiomyopathy

VI.a

Cardiomyopathy (acute, subacute, chronic)

VII - Cardiotoxicity

VII.a

Cardiotoxicity

X - Pulmonary edema - ALI/ARDS

X.b

Pulmonary edema, noncardiogenic (NCPE)
X.c

Interstitial pulmonary edema

XII - Pericardial involvement

XII.b

Pericardial effusion (w/wo tamponade)

XIII - Thrombosis - Embolism

XIII.a

Pulmonary embolism - Venous thrombosis/thromboembolism

XIV - Pleural involvement

XIV.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

XVI - Hemorrhage - Bleeding - Hematoma

XVI.i

Hemoptysis

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

ARDS - Acute lung injury

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.l

Pulmonary infiltrates

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.y

Cytokine release syndrome - Cytokine storm