The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.a

Chest pain (acute or subacute), lone or prominent

Publications

Viñas-Mendieta AE, Valencia-Hernandez HA, Ruiz-Mori E, Gonzalez-Trejo A, Nieto-Dolores AK, Garcia-Cardenas M, Dominguez-Linares A, Espinola-Zavaleta N

Fluoropyrimidine Cardiotoxicity With Overlapping Vasospastic and Pericardial Features: A Diagnostic Challenge.

JACC. Case reports. 2026;31(24):108330

Sara JD, Kaur J, Khodadadi R, Rehman M, Lobo R, Chakrabarti S, Herrmann J, Lerman A, Grothey A

5-fluorouracil and cardiotoxicity: a review.

Therapeutic advances in medical oncology. 2018;10:1758835918780140

Timour Q, Lombard-Bohas C, Slim R, Barel C, Bui-Xuan B, Tabib A, Bricca G, Malonne H, Vial T, Iordescu D, Descotes J

[Cardiotoxicity of 5-fluorouracil: report of 6 cases].

Therapie. 2002;57(3):302-6

McGlinchey PG, Webb ST, Campbell NP

5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report.

BMC cardiovascular disorders. 2001;1:3

Gradishar WJ, Vokes EE

5-Fluorouracil cardiotoxicity: a critical review.

Annals of oncology : official journal of the European Society for Medical Oncology. 1990;1(6):409-14