XXXVI - Autoimmune syndromes - Systemic reactions or conditions
Last update 17/06/2026
May manifest with renal failure, cardiopulmonary syndrome, pulmonary edema (PMID 26713672), ARDS, cardiac arrhythmias, CV instability, seizures or multiorgan failure. See also under IIb. Review at PMID 21561350
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
