The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXII.e

Esophageal toxicity

Publications

Figuero Pérez L, Olivares-Hernández A, Amores-Martín A, Cruz-Hernández JJ, Fonseca-Sánchez E

Acute esophageal necrosis induced by immune checkpoint inhibitors.

Revista espanola de enfermedades digestivas. 2022;114(3):182-183

Horisberger A, La Rosa S, Zurcher JP, Zimmermann S, Spertini F, Coukos G, Obeid M

A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy.

Journal for immunotherapy of cancer. 2018;6(1):156