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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Myocardial dysfunction - Heart failure

I.c

Heart failure (biventricular, congestive)

IV - Heart block (bundle branch-, AV-block)

IV.a

Heart block (bundle branch- or AV-)

V - Myocarditis

V.a

Myocarditis (can be fulminant)

XI - Pulmonary vasculopathies

XI.a

Pulmonary arterial hypertension

XII - Pericardial involvement

XII.b

Pericardial effusion (w/wo tamponade)
XII.n

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XIII - Thrombosis - Embolism

XIII.a

Pulmonary embolism - Venous thrombosis/thromboembolism

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (interstitial lung disease/ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

XXVIII - Large airway involvement including UAO

XXVIII.i

Tongue involvement (edema, glossitis, hematoma)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma
XXIX.i

Exacerbation or deterioration of preexisting COPD

XXXIII - Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.a

Path: Myocarditis
XXXIII.f

Path: Myocardial vasculitis

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)
XXXVI.h

Myasthenia gravis - Myasthenic-like syndrome
XXXVI.v

Temporal arteritis (Horton’s)
XXXVI.ad

Polymyalgia rheumatica