The Drug-Induced Cardiotoxicity Website and App

XXIX.e

XXIX - Small airway involvement

Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

Last update 10/01/2020

(Fr: bronchiolite oblitérante). Pattern distinct from BOOP or AFOP (See section I). It is suspected when airflow obstruction is noted in the context of normal or hyperlucent lungs on chest radiographs and a mosaic or (less often) a tree-in-bud pattern on HRCT studies. HSCT and lung transplant recipients and victims of exposure to noxious gases including chlorine are prone to the development of this complicaton. PMID 20371529, 20441501, 20477273. See under pathology, as bronchiolitis is as the name implies a designation used in pathology

Causative drugs

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic