The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.a

Pulmonary edema, cardiogenic

Publications

Fakhri Y, Dalsgaard M, Nielsen D, Lav Madsen P

5-Fluorouracil-induced acute reversible heart failure not explained by coronary spasms, myocarditis or takotsubo: lessons from MRI.

BMJ case reports. 2016;2016

Wang WS, Hsieh RK, Chiou TJ, Liu JH, Fan FS, Yen CC, Tung SL, Chen PM

Toxic cardiogenic shock in a patient receiving weekly 24-h infusion of high-dose 5-fluorouracil and leucovorin.

Japanese journal of clinical oncology. 1998;28(9):551-4

de Forni M, Malet-Martino MC, Jaillais P, Shubinski RE, Bachaud JM, Lemaire L, Canal P, Chevreau C, Carrié D, Soulié P

Cardiotoxicity of high-dose continuous infusion fluorouracil: a prospective clinical study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1992;10(11):1795-801