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XXIX.c

XXIX - Small airway involvement

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Last update 12/06/2021

(Fr: bronchospasme sévère ou catastrophique). Can be fatal within minutes. Definitive avoidance of the causal drug is imperative. May occur in the context of anaphylaxis (See also IVa). Patients with preexisting asthma, underlying atopy or those who receive B-blockers are at risk

Causative drugs

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic