The Drug-Induced Cardiotoxicity Website and App

Abused drugs/substances (illicit-, street drugs - IV/inhaled)

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.a

Pulmonary arterial hypertension

Publications

Karch SB, Defraia B, Messerini L, Mari F, Vaiano F, Bertol E

Aminorex associated with possible idiopathic pulmonary hypertension in a cocaine user.

Forensic science international. 2014;240:e7-10

Milroy CM, Parai JL

The histopathology of drugs of abuse.

Histopathology. 2011;59(4):579-93

WENDT VE, PURO HE, SHAPIRO J, MATHEWS W, WOLF PL

ANGIOTHROMBOTIC PULMONARY HYPERTENSION IN ADDICTS. "BLUE VELVET" ADDICTION.

JAMA. 1964;188:755-7