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The Drug-Induced Cardiotoxicity Website and App

XXXIII.m

XXXIII - Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

Path: Pulmonary veno-occlusive disease (PVOD)

Last update 17/06/2026

Causative drugs

2

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

Alkylating agents
XIV.p
XXIV.a
Chemotherapy, antineoplastic
I.a
II.a
II.b
III.a
IV.a
VI.a
VI.c
VII.a
VIII.a
X.a
X.b
X.f
XI.a
XI.i
XII.b
XIV.a
XIV.f
XIV.l
XIV.o
XV.a
XVI.e
XXI.a
XXI.c
XXII.b
XXIV.b
XXIV.c
XXIV.f
XXIV.h
XXIV.j
XXIV.k
XXIV.m
XXIV.n
XXIV.p
XXIV.r
XXIV.s
XXIV.t
XXIV.w
XXIV.ad
XXVI.a
XXVIII.a
XXVIII.m
XXIX.a
XXX.i
XXXIII.m
XXXIII.y
XXXIV.e
XXXIV.f
XXXIV.g
XXXVI.b
XXXVI.c
XXXVI.f
XXXVI.q
XXXVIII.k
XXXVIII.n
XXXVIII.y