Back

The Drug-Induced Cardiotoxicity Website and App

I.c

I - Myocardial dysfunction - Heart failure

Heart failure (biventricular, congestive)

Last update 17/06/2026

Can occur as a consequence of several pulmonary obliterative vasculopathies. Cardiac tamponade may mimic this condition. See under VI

Causative drugs

10

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

Adalimumab
XII.g
XII.n
XVI.g
XX.d
XXIV.h
XXIV.p
XXIV.q
XXIV.t
XXVI.a
XXIX.a
XXX.e
XXXIV.b
XXXIV.e
XXXIV.f
XXXIV.g
XXXVI.a
XXXVI.b
XXXVI.c
XXXVIII.c
XXXVIII.q
Bicalutamide
Cabozantinib
XVI.j
CAR T-cell therapy
I.d
I.e
II.f
III.c
III.g
X.b
X.c
XVI.i
XXIV.l
XXXVI.y
Ibrutinib
II.a
II.l
VI.a
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
II.m
III.a
IV.a
V.a
V.e
VI.c
VII.a
X.a
XI.a
XII.b
XIV.a
XIV.i
XV.e
XVI.h
XXI.a
XXII.b
XXIV.d
XXIV.e
XXIV.j
XXIV.k
XXIV.m
XXIV.r
XXIV.w
XXIV.ac
XXIV.ae
XXIX.i
XXX.h
XXXVI.f
XXXVI.q
XXXVI.v
Osimertinib
I.c
II.g
XVI.e
XXIV.a
XXIV.b
XXIV.c
XXIV.n
XXIV.v
XXXIX.a
XXXIX.e
Pembrolizumab
XIII.a
XXVIII.i
XXXIII.a
XXXIII.f
XXXVI.h
XXXVI.ad
Poppy (Papaverum somniferum - Poppy seeds
XXXVIII.d
Sunitinib
I.a