The Drug-Induced Cardiotoxicity Website and App

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXII.b

ARDS - Acute lung injury

Publications

Schneider TM, Klenner F, Brettner F

Extracorporeal Membrane Oxygenation in Nivolumab Associated Pneumonitis.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures). 2017;3(2):84-88

Nishino M, Sholl LM, Hodi FS, Hatabu H, Ramaiya NH

Anti-PD-1-Related Pneumonitis during Cancer Immunotherapy.

The New England journal of medicine. 2015;373(3):288-90