The Drug-Induced Cardiotoxicity Website and App

X.f

X - Pulmonary edema - ALI/ARDS

Capillary leak syndrome (CLS)

Last update 17/06/2026

See also under Xr. Thoracic manifestations may include pulmonary edema, ARDS and pleural effusions (See also under IIa, IIb and Va). Review on causal circumstances and drug at PMID 30404164. Review in french at PMID 25600329

Causative drugs

5

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a
II.b
III.a
IV.a
VI.c
VIII.a
X.a
XI.a
XI.i
XII.b
XIV.f
XIV.l
XIV.o
XV.a
XVI.e
XXI.a
XXI.c
XXIV.c
XXIV.h
XXIV.j
XXIV.k
XXIV.m
XXIV.n
XXIV.p
XXIV.r
XXIV.s
XXIV.t
XXIV.ad
XXVI.a
XXVIII.a
XXVIII.m
XXIX.a
XXX.i
XXXIII.m
XXXIII.y
XXXIV.e
XXXIV.f
XXXIV.g
XXXVI.b
XXXVI.c
XXXVI.f
XXXVI.q
XXXVIII.k
XXXVIII.n
XXXVIII.y