The Drug-Induced Cardiotoxicity Website and App

XXII.f

XXII - Acute respiratory/cardiorespiratory failure

Chest wall muscle rigidity - Stiff/wooden chest

Last update 31/07/2022

Stiff chest from chest wall/respiratory muscle spasm or contracture. May cause apnea, acute respiratory compromise/failure and death. May associate with tetany and/or laryngospasm (see also VIIIe and IXi)

Causative drugs

3

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b
II.a
II.g
II.i
II.n
VI.c
X.b
XI.a
XIII.k
XXII.b
XXII.e
XXII.f
XXXV.b
XXXVIII.d
XXXVIII.h