The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXII.b

ARDS - Acute lung injury

Publications

Aghabiklooei A, Edalatparvar M, Zamani N, Mostafazadeh B

Prognostic factors in acute methadone toxicity: a 5-year study.

Journal of toxicology. 2014;2014:341826

Aghabiklooei A, Shadnia S, Hassanian-Moghaddam H, Zamani N

Acute respiratory distress syndrome caused by methadone syrup.

Arhiv za higijenu rada i toksikologiju. 2013;64(3):439-43

Martin M, Daoudal P, Bein C, Bazzi N, Bourscheid D, Floriot C

[Inhaled methadone-induced non cardiogenic pulmonary edema with Acute Respiratory Distress Syndrome].

Presse medicale (Paris, France : 1983). 2011;40(4 Pt 1):436-8

Ridgway ZA, Pountney AJ

Acute respiratory distress syndrome induced by oral methadone managed with non-invasive ventilation.

Emergency medicine journal : EMJ. 2007;24(9):681

Schaaf JT, Spivack ML, Rath GS, Snider GL

Pulmonary edema and adult respiratory distress syndrome following methadone abuse.

The American review of respiratory disease. 1973;107(6):1047-51