The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.n

Respiratory arrest - Apnea

Publications

Lusetti M, Licata M, Silingardi E, Reggiani Bonetti L, Palmiere C

Therapeutic and recreational methadone cardiotoxicity.

Journal of forensic and legal medicine. 2016;39:80-4

Swenson O

Accidental methadone intoxication masquerading as asthma exacerbation with respiratory arrest in a six-year-old boy.

Delaware medical journal. 2015;87(5):147-9

Aghabiklooei A, Hassanian-Moghaddam H, Zamani N, Shadnia S, Mashayekhian M, Rahimi M, Nasouhi S, Ghoochani A

Effectiveness of naltrexone in the prevention of delayed respiratory arrest in opioid-naive methadone-intoxicated patients.

BioMed research international. 2013;2013:903172