XXXVI - Autoimmune syndromes - Systemic reactions or conditions
Last update 17/06/2026
Including granulomatosis with polyangiitis. With or without ANCA or DAH present. Capillaritis is sometimes documented on pathology. In cases due to PTU or cocaine/levamisole, very high titres of multispecific ANCA can be present. See also under III and XII
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
