The Drug-Induced Cardiotoxicity Website and App

XXIV.g

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

Amiodarone pulmonary toxicity - Amiodarone lung

Last update 17/06/2026

(Fr: toxicité pulmonaire de l'amiodarone). Amiodarone pulmonary toxicity typically manifests with insidious, often bilateral asymmetrical pulmonary opacities or areas of consolidation with, typically, increased CT numbers. Imaging, BAL, pathology are distinctive. APT typically exhibits features of endogenous lipoid pneumonia (i.e. phospholipidosis)

Causative drugs

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic