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XXXII.b

XXXII - Esophageal pathology

Esophageal pathology (erosion, ulcer, tear, rupture, fistula)

Last update 03/02/2019

May cause chest pain (See under XIb). Including drug-induced ulcers (PMID 26230070). Boerhaave's syndrome (BS) corresponds to a longitudinal esophageal rupture sometimes vomiting-induced, whcih may lead to bacterial mediastinitis, pneumothorax and/or empyema. BS manifests with mediothoracic chest pain and extraesopageal air on imaging.

Causative drugs

8

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

Acetylcysteine (N-acetylcysteine)
XXVIII.a
XXXII.e
Bariatric surgery (status post-)
XII.i
XIV.a
XIV.g
Doxycycline
XXIV.a
Household/cleansing agents
XXIV.b
XXIX.e
XXXII.g
Laundry detergent pods
XXII.a
XXII.e
XXVIII.g
XXXVIII.a
Pentazocine
X.b
XI.a
XI.b
XIII.i
XIII.k
XXVII.a
XXVII.b
XXXVIII.d
Pills - Tablets
XV.a
XXXII.b
XXXII.i
Proton beam therapy
XIV.k
XXIV.h
XXIV.u