The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.a

Pulmonary arterial hypertension

Publications

Houck RJ, Bailey GL, Daroca PJ Jr, Brazda F, Johnson FB, Klein RC

Pentazocine abuse. Report of a case with pulmonary arterial cellulose granulomas and pulmonary hypertension.

Chest. 1980;77(2):227-30

Farber HW, Falls R, Glauser FL

Transient pulmonary hypertension from the intravenous injection of crushed, suspended pentazocine tablets.

Chest. 1981;80(2):178-82

Lundquest DE, Young WK, Edland JF

Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse.

Journal of forensic sciences. 1987;32(3):798-801