The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIII.k

Foreign body pulmonary vasculopathy (Excipient lung disease)

Publications

Fields TA, McCall SJ, Reams BD, Roggli VL, Palmer SM, Howell DN

Pulmonary embolization of microcrystalline cellulose in a lung transplant recipient.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2005;24(5):624-7

Farber H, Glauser FL

The effect of oral hydralazine on the pulmonary hemodynamics of patients with pulmonary foreign body granulomatosis.

Chest. 1982;82(6):708-12

Zeltner TB, Nussbaumer U, Rudin O, Zimmermann A

Unusual pulmonary vascular lesions after intravenous injections of microcrystalline cellulose. A complication of pentazocine tablet abuse.

Virchows Archiv. A, Pathological anatomy and histology. 1982;395(2):207-16