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The Drug-Induced Cardiotoxicity Website and App

BCG therapy (topical instillations in the urinary bladder)

PMID 26077036, 30526332

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIV - Pleural involvement

XIV.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

XX - Vasculitis

XX.c

Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

XXI - Mediastinal involvement/injury

XXI.a

Lymphadenopathy (intrathoracic)

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

ARDS - Acute lung injury

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (interstitial lung disease/ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.f

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

XXIX - Small airway involvement

XXIX.d

Cough (lone)

XXX - Imaging features

XXX.b

Imaging: A miliary pattern (diffuse random micronodules)
XXX.n

Imaging: A 'tree-in-bud' pattern

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.h

Myasthenia gravis - Myasthenic-like syndrome
XXXVI.i

Guillain-Barré (or GB-like) syndrome (w/wo ARF)
XXXVI.k

Multiple organ dysfunction/failure (MODS/MOF)

XXXVIII - Miscellaneous - Varia

XXXVIII.a

Upper airway obstruction other than angioedema or hematoma
XXXVIII.k

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)