The Drug-Induced Cardiotoxicity Website and App

BCG therapy (topical instillations in the urinary bladder)

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXVI.k

Multiple organ dysfunction/failure (MODS/MOF)

Publications

Delimpoura V, Samitas K, Vamvakaris I, Zervas E, Gaga M

Concurrent granulomatous hepatitis, pneumonitis and sepsis as a complication of intravesical BCG immunotherapy.

BMJ case reports. 2013;2013

Kaklamanos M, Hardavella G, Trigidou R, Dionellis G, Paissios N, Koulouris N, Goritsas C

Multi-organ failure with atypical liver granulomas following intravesical Bacillus Calmette-Guerin instillation.

World journal of hepatology. 2011;3(3):79-82