The Drug-Induced Cardiotoxicity Website and App

X.i

X - Pulmonary edema - ALI/ARDS

Pulmonary edema/ARDS of the ATRA syndrome (see Xab)

Last update 30/12/2014

See under Xab. The syndrome includes fever, weight gain, peripheral edema, respiratory distress, interstitial pulmonary opacities, pleural and/or pericardial effusions, hypotension and renal failure. See also under IIb (ARDS) and Va

Causative drugs

2

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic