The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.i

Pulmonary edema/ARDS of the ATRA syndrome (see Xab)

Publications

Işık P, Çetin I, Tavil B, Azik F, Kara A, Yarali N, Tunc B

All-transretinoic acid (ATRA) treatment-related pancarditis and severe pulmonary edema in a child with acute promyelocytic leukemia.

Journal of pediatric hematology/oncology. 2010;32(8):e346-8

Ahmed Z, Shaikh MA, Raval A, Mehta JB, Byrd RP Jr, Roy TM

All-trans retinoic acid syndrome: another cause of drug-induced respiratory failure.

Southern medical journal. 2007;100(9):899-902