The Drug-Induced Cardiotoxicity Website and App

Hydrocarbons (petrochemicals: petroleum, petrolatum, paraffin, vaseline, naphta, jet fuel (kerosene), Diesel, gasoil), ointments, salad oil, variegated oils, butter). Aspirated

Liquid (fluid) hydrocarbons or hydrocarbon mist (salad oil, paraffin, vaseline, parpetroleum, petrolatum, lamp oil, kerdane, jet fuel, kerosene, turpentine, Diesel fuel, Jet-A fuel, JP-8; paint thinner, furniture polish, bath oils or ointments (PMID 24911841, 25868376, 26063683), shark oil, butter). ‘Pneumonitis’ from these chemicals/fuels and compounds is a disease of fire-eaters, or it may follow siphoning and unintentional aspiration of gasoline, Diesel or other liquid fuels in children or in adults (PMID 30581584, 42662264). Therapeutic BAL has been used in some instances. Fluid hydrocarbons can cause an acute inflammatory pneumopathy w/wo chest pain, pleural effusion, cavitaion, pneumatoceles, pneumothorax, pneumomediastinum and secondary infection. Acute mortality is about 1%. Recovery is in weeks or months. Suggestive changes on pathology may wane with time (PMID 30581584). Although sometimes effective, corticosteroid therapy is associated with unpredictable results.

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic