Specialities: Gastroenterology · Internal medicine · Rheumatology
Hypesrentitivity infusion reactions are common (PMID 12818276). For those ILD cases exposed to methotrexate concomitantly, drug causality assessment in regards to infliximab is difficult.
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pneumonitis (interstitial lung disease/ILD)
Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
Acute eosinophilic pneumonia (AEP)
Pulmonary fibrosis
Progression, acceleration or exacerbation of preexisting ILD/fibrosis
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
Rapidly progressive ILD/pulmonary fibrosis (a.k.a. Hamman-Rich syndrome)
