The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIX.a

Bronchospasm - Wheezing - Asthma

Publications

Uyanikoglu A, Ermis F, Akyuz F, Pinarbasi B, Baran B, Aydogan T, Demir K, Besisik F, Kaymakoglu S

Infliximab in inflammatory bowel disease: attention to adverse events.

European review for medical and pharmacological sciences. 2014;18(16):2337-42

Guilleminault L, Carré P, Beau-Salinas F, Taillé C, Dieudé P, Crestani B, Diot P, Marchand-Adam S

Asthma unmasked with tumor necrosis factor-α-blocking drugs.

Chest. 2011;140(4):1068-1071

Dubey S, Kerrigan N, Mills K, Scott DG

Bronchospasm associated with anti-TNF treatment.

Clinical rheumatology. 2009;28(8):989-92