The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Left or biventricular dysfunction/failure

Publications

Elkattawy S, Alyacoub R, Al-Nassarei A, Younes I, Ayad S, Habib M

Cocaine induced heart failure: report and literature review.

Journal of community hospital internal medicine perspectives. 2021;11(4):547-550

Arenas DJ, Beltran S, Zhou S, Goldberg LR

Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis.

Scientific reports. 2020;10(1):19795

Cooper CJ, Said S, Alkhateeb H, Rodriguez E, Trien R, Ajmal S, Blandon PA, Hernandez GT

Dilated cardiomyopathy secondary to chronic cocaine abuse: a case report.

BMC research notes. 2013;6:536

Arzola-Castañer D, Johnson C

Cocaine-induced myocardial infarction associated with severe reversible systolic dysfunction and pulmonary edema.

Puerto Rico health sciences journal. 2004;23(4):319-22