The Drug-Induced Cardiotoxicity Website and App
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Death following exposure or poisoning
Publications
Nicol JJ, Yarema MC, Jones GR, Martz W, Purssell RA, MacDonald JC, Wishart I, Durigon M, Tzemis D, Buxton JA
Deaths from exposure to paramethoxymethamphetamine in Alberta and British Columbia, Canada: a case series.
CMAJ open. 2015;3(1):E83-90
Involvement of amphetamines in sudden and unexpected death.
Journal of forensic sciences. 2009;54(2):478-85
Underlying causes of cocaine, amphetamine and opioid related deaths in Australia.
Journal of clinical forensic medicine. 2005;12(4):187-95