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The Drug-Induced Cardiotoxicity Website and App

Methamphetamine

Met/Meth is an abused drug/substance. Manufacture of met in so-called meth-labs can injure bystanders, family, children, law officers, coroners, firemen and/or forensic people. See also under amphetamine and PMID: 10408124, 16438482, 1758482, 18166274, 19936975, 9358986, 21683529. When cut with talc, methamphetamine can cause pneumoconiosis and PMF (PMID 23050878). Examination of the oral cavity for meth-mouth is indicated (PMID 21874893, 25662544). Management issues at PMID 25724076. Meth is sometimes carried by body-packers (PMID 19342282)

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Myocardial dysfunction - Heart failure

I.e

Acute respiratory or cardiopulmonary failure

II - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.m

Sudden cardiac death

III - Myocardial ischemia - Coronary artery disease

III.a

Coronary artery disease (acute) - Myocardial ischemia/infarction

VI - Cardiomyopathy

VI.a

Cardiomyopathy (acute, subacute, chronic)

X - Pulmonary edema - ALI/ARDS

X.b

Pulmonary edema, noncardiogenic (NCPE)

XI - Pulmonary vasculopathies

XI.a

Pulmonary arterial hypertension

XV - Chest pain

XV.a

Chest pain (acute or subacute), lone or prominent

XVI - Hemorrhage - Bleeding - Hematoma

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

XX - Vasculitis

XX.c

Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

ARDS - Acute lung injury

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.k

Multiple organ dysfunction/failure (MODS/MOF)

XXXVIII - Miscellaneous - Varia

XXXVIII.d

Death following exposure or poisoning
XXXVIII.s

CNS involvement/dysfunction/damage