The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Publications

Ramirez FD, Femenía F, Simpson CS, Redfearn DP, Michael KA, Baranchuk A

Electrocardiographic findings associated with cocaine use in humans: a systematic review.

Expert review of cardiovascular therapy. 2012;10(1):105-27

Secemsky E, Lange D, Waters DD, Goldschlager NF, Hsue PY

Hemodynamic and arrhythmogenic effects of cocaine in hypertensive individuals.

Journal of clinical hypertension (Greenwich, Conn.). 2011;13(10):744-9

Levenson T, Greenberger PA, Donoghue ER, Lifschultz BD

Asthma deaths confounded by substance abuse. An assessment of fatal asthma.

Chest. 1996;110(3):604-10