The Drug-Induced Cardiotoxicity Website and App

XXXVI.e

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

ANCA positivity. Subclinical or with clinical manifestations

Last update 02/04/2026

Antineutrophil cytoplamic antibodies (ANCA). More often p- than c-ANCA. Exact typing and target antigen determination are important. Polyspecificty and the presence of anti-HNE Ab are suggestive of the drug etiology. Subclinical organ damage or dysfuction should be investigated.

Causative drugs

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

Trimethoprim sulfamethoxazole (TMP-SMX)