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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X - Pulmonary edema - ALI/ARDS

X.b

Pulmonary edema, noncardiogenic (NCPE)

XII - Pericardial involvement

XII.c

Hemopericardium - Bloody pericardial effusion

XIV - Pleural involvement

XIV.e

Hemothorax - Serosanguineous pleural effusion

XVI - Hemorrhage - Bleeding - Hematoma

XVI.c

Hematoma of/around central airway wall potentially causing UAO
XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI.i

Hemoptysis
XVI.p

Submucosal airway petechiae/hemorrhage

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

ARDS - Acute lung injury

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (interstitial lung disease/ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXVIII - Large airway involvement including UAO

XXVIII.a

Angioedema (may cause UAO, asphyxia and death)

XXXII - Esophageal pathology

XXXII.a

Esophageal hematoma (may cause chest pain and/or tracheal compression)

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m

DRES syndrome - DRESS-like reaction
XXXVI.p

Systemic inflammatory response

XXXVIII - Miscellaneous - Varia

XXXVIII.k

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)