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The Drug-Induced Cardiotoxicity Website and App

Aspirin (Salicylate-ASA) - Aspirin containing drugs

Specialities: Cardiology - Cardiovascular medicine · ICU - I.C.U. · Pulmonary medicine

Aspirin-exacerbated respiratory disease (AERD; PMID 24961377) is a naturally-occurring state where aspirin and NSAIDs can produce acute exacerbations and asthma attacks. Tests to document AERD at PMID 17521312. For induction of AS tolerance see PMID 12532116, 23861151, 24369807, 24468245.

Chronic or excessive intake of aspirin can produce pulmonary edema and ARDS (PMID 9743184, 21297545 , 27531848)

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Myocardial dysfunction - Heart failure

I.d

Cardiovascular collapse - Cardiogenic shock - Hypotension

III - Myocardial ischemia - Coronary artery disease

III.c

Coronary vasospasm - Vasospastic angina

IV - Heart block (bundle branch-, AV-block)

IV.a

Heart block (bundle branch- or AV-)

X - Pulmonary edema - ALI/ARDS

X.b

Pulmonary edema, noncardiogenic (NCPE)

XIV - Pleural involvement

XIV.e

Hemothorax - Serosanguineous pleural effusion

XV - Chest pain

XV.a

Chest pain (acute or subacute), lone or prominent

XVI - Hemorrhage - Bleeding - Hematoma

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI.h

Coagulopathy
XVI.i

Hemoptysis

XX - Vasculitis

XX.c

Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

ARDS - Acute lung injury

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.f

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

XXVIII - Large airway involvement including UAO

XXVIII.a

Angioedema (may cause UAO, asphyxia and death)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma
XXIX.c

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

XXXIII - Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.j

Path: Pulmonary edema (see also II/IIa)

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)