The Drug-Induced Cardiotoxicity Website and App

Tobacco smoke - Cigarette smoking

And/or tobacco substitutes. PMID 22365253, 23001806, 23999882. Passive smoking (secondhand smoke) may cause part of these manifestations, particularly in children. Review on imaging of smoking-related ILD: PMID 24480144. Tobacco smoking may alter the pharmacokinetics of anticancer agents, being detrimental in terms of therapeutic efficacy (PMID: 24926542). Smoking in survivors of Hodgkin's and other malignant lymphomas should be discouraged, as risk of developing lung cancer is makedly increased. Reviews at PMID 25415179, 25415179, 25498399, 29222007. Imaging and pathology at PMID 26479130.

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.h

Pulmonary fibrosis