The Drug-Induced Cardiotoxicity Website and App

Fluid silicone is used by cosmetic surgeons or by illegal 'lay' surgeons, or by incompetent and unscrupulous operators (PMID; 16738424) for the purpose of body augmentation mammaplasty (then in the breasts) or in the context of transsexualism. The compound may cause severe or fatal silicone embolism syndrome with DAH, ARDS and/or MODS

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic