The Drug-Induced Cardiotoxicity Website and App

Corticosteroids, systemic (oral, parenteral)

Longterm oral or parenteral CST (PMID 11239846) poses the risk of opportunistic pulmonary (PMID 20736243, 2817582) and/or systemic infections (PMID 23982055). Continued attention is required as the use of costicosteroids may be increasing (PMID 21393338)

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic