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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

II.l

Cardiac- cardiorespiratory/pulmonary arrest

X - Pulmonary edema - ALI/ARDS

X.b

Pulmonary edema, noncardiogenic (NCPE)
X.d

Fluid retention

XIII - Thrombosis - Embolism

XIII.f

Fat/oil embolism - The FES embolism syndrome

XV - Chest pain

XV.a

Chest pain (acute or subacute), lone or prominent

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

ARDS - Acute lung injury

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma

XXXIII - Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.o

Path: Lipid/fat embolism (see also VIe)

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

XXXVIII - Miscellaneous - Varia

XXXVIII.a

Upper airway obstruction other than angioedema or hematoma
XXXVIII.k

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)